How Human-Centric R&D Is Redefining Drug Discovery
Turning human data into breakthrough drugs
TL;DR: Oncology R&D is shifting from animal proxies to patient-derived, clinically grounded models.
Reverse translation flips R&D: start with human clinical data → discover mechanisms → build preclinical models, not vice versa.
Case study: three‑cell niches (CD4 T, CD8 T, dendritic cell) found in patient tumors drive response to PD‑1 therapy, missed by co…
